Age-related decline in sperm DNA integrity in patients evaluated for male infertility

The purpose of this study was to analyze the relationship of male age and DNA integrity in men presenting for investigation of infertility. We found that men 45 years and older had significantly greater DNA fragmentation than younger men.

Fertil Steril. 2006 Feb;85(2):496-9. Moskovtsev SI, Willis J, Mullen JB.